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A​CCMetrics is an image analysis software which allows ​automatic quantification of nerve fibre metrics from single or multiple CCM images.

Product specification: Corneal Nerve Fibre Analyser

Product description: ACCMetrics V.2 automatically extracts and quantifies nerve fibre metrics in images obtained using the Heidelberg HRT III corneal confocal microscope. It quantifies the Nerve Fibre Length (NFL), Nerve Fibre Density (NFD), Nerve Branch Density (NBD), Nerve Fibre Total Branch Density (CTBD), Nerve Fibre Area (CNFA), Nerve Fibre Width (CNFW), Nerve Fibre Orientation Histogram (NFOH) and Nerve Fibre Width Histogram (NFWH) from single or multiple CCM images with a field of view of 400x400 mm2.

This software has applications in the quantification of corneal nerve abnormalities for a variety of peripheral neuropathies such as diabetic neuropathy, chemotherapy induced peripheral neuropathy, sarcoid neuropathy, CMT1A, Fabry disease etc.

Product requirements: 64 bit computer processor.

***If the following error message appears "Could not find the version 8.3 of the MCR" simply install version 8.3 64 bit from the link (http://www.mathworks.com/products/compiler/mcr/) and then restart***

 

Cut-off point​s: Automated quantification of CNFD and CNFL with​ ACCMetrics provides high sensitivity/specificity for diagnosis of peripheral neuropathy and is associated with a high odds ratio (OR) (Petropoulos et al. 2014). A CNFD result of 14.7 no./mm2 is associated with sens/spec of 0.76/0.72 and OR of 11.0. A CNFL result of 14.6 mm/mm2 is associated with sens/spec of 0.77/0.74 and OR of 12.9.

Acknowledgements: 

If you publish results using ​ACCMetrics, we expect acknowledgement and appropriate citation of the following papers, which describe the design and validation of the software:

Software design:

Dabbah , MA, Graham, J, Petropoulos, I, Tavakoli, M, Malik, RA (2011). ​Automatic Analysis of Diabetic Peripheral Neuropathy using Multi-scale Quantitative Morphology of Nerve Fibres in Corneal Confocal Microscopy Imaging, Journal of Medical Image Analysis 15(5), 738-747.

Dabbah, MA, Graham, J, Petropoulos, I, Tavakoli, M, Malik, RA (2010). Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images, Med Image Comput Comput Assist Interv 13, 300-307.

An Automatic Tool for Quantification of Nerve Fibres in Corneal Confocal Microscopy Images. Chen, X. et al. (2016)  IEEE Transactions on Biomedical Engineering. in preprint 

 

Validation of the corneal nerve parameters:​

Petropoulos IN, Alam U, Fadavi H, Marshall A, Asghar O, Dabbah MA, et al. Rapid automated diagnosis of diabetic peripheral neuropathy with in vivo corneal confocal microscopy. Investigative ophthalmology & visual science 2014; 55:2071-2078.

Petropoulos IN, Manzoor T, Morgan P, Fadavi H, Asghar O, Alam U, et al. Repeatability of in vivo corneal confocal microscopy to quantify corneal nerve morphology. Cornea 2013; 32:e83-89.

Chen X, Graham J, Dabbah MA, Petropoulos IN, Ponirakis G, Asghar O, et al. Small nerve fiber quantification in the diagnosis of diabetic sensorimotor polyneuropathy: comparing corneal confocal microscopy with intraepidermal nerve fiber density. Diabetes Care 2015; 38:1138-1144.

 

Normative values for CCM:

Tavakoli M, Ferdousi M, Petropoulos IN, Morris J, Pritchard N, Zhivov A, et al. Normative values for corneal nerve morphology assessed using corneal confocal microscopy: a multinational normative data set. Diabetes Care 2015; 38:838-843.

 

Product Training:  2 day training courses are available in both Manchester, England and Doha, Qatar. These practical hands-on courses have been established to train researchers in CCM image acquisition and image analysis.

  • Dr.  ​Maryam Ferdousi at the University of Manchester, UK
  • Dr. Ioannis Petropoulos at Weill Cornell Medicine in Qatar 

To book a course please contact Georgios Ponirakis at ccmanalytics@qatar-med.cornell.edu.​​

















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ACCMetrics

Corneal Nerve Fibre Analyser

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MAN_002-3494548-v2-UMIP Annual Research Licence C2G final 1.00

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Term: 12 months
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This is a free of charge, annual licence for the use of the software by commercial organisations only.

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Term: 12 months
Seats: 1 seat(s)

Price excl. VAT: Free of charge